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- W2357894070 abstract "OBJECTIVE:To investigate the effect of Bupleuri liver-coursing powder on mammary gland hyperplasia induced by liver depression in rats.METHODS:Liver depression mammary gland hyperplasia rats model were constructed by irritating rats with clipping the tails once a day for 30 d,combined with im estradiol benzoate(0.5 mg/kg),once a day for 25 d,then progesterone(4 mg/kg)im administration,once a day for 5 d,to culture the mammary gland hyperplasia induced by liver depression rats model.Eighty Wister rats were divided into normal control group(isovolumic normal saline),model group(isovolumic normal saline),prevention group [replication model and ig administration,once a day for 60 d,6.3 g(medicinal materials)/kg],tamoxifen group(1.8 mg/kg),Rupixiao tablets group(0.6 g/kg),and Bupleuri liver-coursing powder high,medium and low dose groups[12.6,6.3,3.15 g(medicinal materials)/kg].In addition to the preventive medication,the other groups were given ig administration,once a day for 30 d.The breast diameter and nipple height were detected,second pair of rats breast were weighed,the content of rats serum gonadotrophin releasing hormone(Gn RH),follicle stimulating hormone(FSH),luteinizing hormone(LH),prolactin(PRL),estradiol(E2)and progesterone(P),5-hydroxytryptamine(5-HT)and vascular endothelial growth factor(VEGF)in the breast tissue,basic fibroblast growth factor(b FGF) were detected by ELISA.RESULTS:Compared with normal control group,the breast diameter,nipple height,breast mass were increased in model group,the content of serum Gn RH,FSH,PRL,E2 and 5-HT were increased;serum P content was reduced;VEGF and b FGF in mammary gland tissue were increased.The differences were statistically significant(P0.01 or P0.05).Compared with model group,the breast diameter,nipple height,breast mass of rats were decreased in prevention group and Bupleuri liver-coursing powder high and medium dose groups;the content of serum Gn RH,FSH,E2 and 5-HT were decreased;b FGF in mammary gland tissue were decreased;serum P content was increased in prevention group and Bepleuri liver-coursing powder high dose group;VEGF in mammary gland tissue were decreased;serum PRL content was decreased in prevention group and Bupleuri liver-coursing powder high,medium and low dose groups;serum LH activity was increased in Bupleuri liver-coursing powder high dose group.There was statistical significant difference(P0.01 or P0.05).CONCLUSIONS:Bupleuri liver-coursing powder have certain protection effects on model rats with mammary gland hyperplasia,and its mechanism was related to the improvement of serum hormone levels." @default.
- W2357894070 created "2016-06-24" @default.
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- W2357894070 date "2015-01-01" @default.
- W2357894070 modified "2023-09-24" @default.
- W2357894070 title "Protection Effect of Bupleuri Liver-coursing Powder on Mammary Gland Hyperplasia Induced by Liver Depression in Rats" @default.
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