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- W2357900405 abstract "OBJECTIVE: To investigate the inhibition effect of Hydroxycamptothecin sustained-released tablets(HCPT)implanted into brain on C6 glioma in rats. METHODS: The C6 glioma cells were transplanted into brain of rats, and C6 glioma model was established after 10 days. Model rats were divided into model control group, blank control group (implanting sustained-release tablets which were not containing HCPT), intravenous injection therapy group (HCPT injection 2 mg·kg-1), intratumoral injection therapy group (HCPT injection containing about HCPT 2.4 mg), carcinoma implantation therapy group (HCPT sustained-release tablets containing about 2.4 mg) with each group of 10 rats. The median survival time was compared among those groups after giving relevant drugs. The growth of glioma was detected by MRI dynamically. RESULTS: Compared with model control group, the median survival time of cerebral implantation group increased significantly while other groups had no significant difference. MRI results showed that tumor volume of cerebral implantation group had no significant increase after 15 days of treatment, and at 15th day tumor volume decreased slightly. The tumor volume of other groups all increased. CONCLUSION: HCPT sustained-release tablets implanted into brain can increase the median survival time of model rats significantly, and neurotoxic effect of it on cerebral tissue is to be proven by further experiment." @default.
- W2357900405 created "2016-06-24" @default.
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- W2357900405 date "2011-01-01" @default.
- W2357900405 modified "2023-09-25" @default.
- W2357900405 title "Inhibition Effect of Hydroxycamptothecin Sustained-release Tablets Implanted into Brain on C6 Glioma in Rats" @default.
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