Matches in SemOpenAlex for { <https://semopenalex.org/work/W2357934937> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W2357934937 endingPage "247" @default.
- W2357934937 startingPage "243" @default.
- W2357934937 abstract "The glial cell line-derived neurotrophic factor(GDNF) plays a very important role in the regeneration of the nervous system. Based on the results of the X-ray structure analysis of rat GDNF, human GDNF gene was modified with deletion and insertion mutagenesis by using PCR methods. The various mutants were all highly expressed in E.coli. The recombinant proteins were purified and their survival-promoting activities were determined by using cultures of the spinal cord neurons of embryonic mouse. The results showed that the cystine knot motif was critical for the maintenance of GDNF structure the alpha-helix, finger 1 and finger 2 region were critical for GDNF neurotrophic activity and the N-terminus of human GDNF was not essential for its biological functions." @default.
- W2357934937 created "2016-06-24" @default.
- W2357934937 creator A5008473333 @default.
- W2357934937 creator A5009621777 @default.
- W2357934937 creator A5025148084 @default.
- W2357934937 creator A5032686473 @default.
- W2357934937 creator A5040320732 @default.
- W2357934937 date "2000-01-01" @default.
- W2357934937 modified "2023-09-23" @default.
- W2357934937 title "A Structure-function Analysis of Human GDNF." @default.
- W2357934937 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12075448" @default.
- W2357934937 hasPublicationYear "2000" @default.
- W2357934937 type Work @default.
- W2357934937 sameAs 2357934937 @default.
- W2357934937 citedByCount "2" @default.
- W2357934937 countsByYear W23579349372015 @default.
- W2357934937 crossrefType "journal-article" @default.
- W2357934937 hasAuthorship W2357934937A5008473333 @default.
- W2357934937 hasAuthorship W2357934937A5009621777 @default.
- W2357934937 hasAuthorship W2357934937A5025148084 @default.
- W2357934937 hasAuthorship W2357934937A5032686473 @default.
- W2357934937 hasAuthorship W2357934937A5040320732 @default.
- W2357934937 hasConcept C104317684 @default.
- W2357934937 hasConcept C143065580 @default.
- W2357934937 hasConcept C153911025 @default.
- W2357934937 hasConcept C160539049 @default.
- W2357934937 hasConcept C170493617 @default.
- W2357934937 hasConcept C185856081 @default.
- W2357934937 hasConcept C40767141 @default.
- W2357934937 hasConcept C55493867 @default.
- W2357934937 hasConcept C86803240 @default.
- W2357934937 hasConcept C94296188 @default.
- W2357934937 hasConcept C95444343 @default.
- W2357934937 hasConceptScore W2357934937C104317684 @default.
- W2357934937 hasConceptScore W2357934937C143065580 @default.
- W2357934937 hasConceptScore W2357934937C153911025 @default.
- W2357934937 hasConceptScore W2357934937C160539049 @default.
- W2357934937 hasConceptScore W2357934937C170493617 @default.
- W2357934937 hasConceptScore W2357934937C185856081 @default.
- W2357934937 hasConceptScore W2357934937C40767141 @default.
- W2357934937 hasConceptScore W2357934937C55493867 @default.
- W2357934937 hasConceptScore W2357934937C86803240 @default.
- W2357934937 hasConceptScore W2357934937C94296188 @default.
- W2357934937 hasConceptScore W2357934937C95444343 @default.
- W2357934937 hasIssue "3" @default.
- W2357934937 hasLocation W23579349371 @default.
- W2357934937 hasOpenAccess W2357934937 @default.
- W2357934937 hasPrimaryLocation W23579349371 @default.
- W2357934937 hasRelatedWork W1982443887 @default.
- W2357934937 hasRelatedWork W2002771209 @default.
- W2357934937 hasRelatedWork W2016730284 @default.
- W2357934937 hasRelatedWork W2041095748 @default.
- W2357934937 hasRelatedWork W2087262420 @default.
- W2357934937 hasRelatedWork W2110682302 @default.
- W2357934937 hasRelatedWork W2377845333 @default.
- W2357934937 hasRelatedWork W2415593940 @default.
- W2357934937 hasRelatedWork W2753184583 @default.
- W2357934937 hasRelatedWork W2523859916 @default.
- W2357934937 hasVolume "32" @default.
- W2357934937 isParatext "false" @default.
- W2357934937 isRetracted "false" @default.
- W2357934937 magId "2357934937" @default.
- W2357934937 workType "article" @default.