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- W2357948465 abstract "Objective To observe the impact of glycyrrhizin(GL) and dexamethasone(DEX) on podocyte apoptosis,and explore the protective mechanism of GL on renal function. Methods Podocyte injury model induced by puromycin aminonucleoside(PAN) was established,and podocytes were treated for 48 hours by using 12.5 mg·L-1,25.0 mg·L-1,50.0 mg·L-1,75.0 mg·L-1,100.0 mg·L-1 PAN,respectively.The apoptotic podocyte cells were revealed with FITC-Annexin V and propidium lodide(PI) assay.Divide MPC5 was divided into control group(appling RPMI 1640 at same quantity),PAN group(PAN 50.0 mg·L-1),DEX1 group(PAN 50.0 mg·L-1+DEX 0.1 μmol·L-1),DEX2 group(PAN 50.0 mg·L-1+DEX 1.0 μmol·L-1),DEX3 group(PAN 50.0 mg·L-1+DEX 10.0 μmol·L-1),GL1 group(PAN 50.0 mg·L-1+GL 400.0 mg·L-1),GL2 group(PAN 50.0 mg·L-1+GL 600.0 mg·L-1),and GL3 group(PAN 50.0 mg·L-1+GL 800.0 mg·L-1).Podocyte apoptosis was assessed in 48 hours using flow cytometry. Results Compared with control group,the percentage of apoptotic podocyte cells was obviously increased after 50.0 mg·L-1 PAN treatment(P0.05),but it was significantly increased after 75.0 mg·L-1,100.0 mg·L-1 PAN(Pa0.01).Compared with PAN group,the percentage of apoptotic podocyte cells were obviously lower in DEX1 and 2 group(Pa0.05),and was significantly lower in DEX3 group(P0.01).Compared with control group,the percentage of apoptotic podocyte cells was significantly lower in all GL groups(Pa0.01).The higher GL concentration,the higher podocyte apoptotic rate(P0.05). Conclusions Fifty point zero mg·L-1 PAN is the appropriate concentration for setting up an in vitro podocyte injury model;DEX has suppressive effects with concentration-dependent on process of podocyte injure by PAN while GL also has effective protection in podocyte injury.The ability of anti-apoptosis of GL on podocyte depends on its concentration." @default.
- W2357948465 created "2016-06-24" @default.
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- W2357948465 date "2011-01-01" @default.
- W2357948465 modified "2023-09-27" @default.
- W2357948465 title "Study on Intervention of Glycyrrhizin and Dexamethasone on Podocytes Injury Induced by Puromycin Aminonucleoside in vitro" @default.
- W2357948465 hasPublicationYear "2011" @default.
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