Matches in SemOpenAlex for { <https://semopenalex.org/work/W2357954023> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W2357954023 abstract "AIM:To observe the effects of bupivacaine at different concentrations on intracellular free Ca2+ concentration([Ca2+]i) in isolated rat ventricular myocytes induced by KCl using laser scanning confocal microscope(LSCM),and to investigate the mechanism of cardiotoxicity of bupivacaine.METHODS:The cultured ventricular myocytes of newborn rats were divided randomly into 4 groups:the control group(group C),the group of bupivacaine at 10 μmol/L(group B1),the group of bupivacaine at 50 μmol/L(group B2) and the group of bupivacaine at 100 μmol/L(group B3).The fluorescent intensity(FI) of intracellular Ca2+ in single cultured cardiomyocytes of newborn rats loaded with Fluo-3/AM was observed by LSCM in order to compare the effects of bupivacaine at different concentrations on the change of [Ca2+]i induced by KCl.RESULTS:There was no difference in the changes of intracellular Ca2+ FI in rat ventricular myocytes induced by KCl in group B1 compared with those in group C(P0.05).Intracellular Ca2+ FI in rat ventricular myocytes induced by KCl was inhibited significantly in group B2 and B3 compared with that in group C(P0.05).CONCLUSION:There is no significant effect of bupivacaine at low concentration on intracellular Ca2+ in rat ventricular myocytes induced by KCl.Bupivacaine at high concentraton could significantly inhibit the effects on [Ca2+]i in rat ventricular myocytes induced by KCl.Bupivacaine could inhibit Ca2+ transsarcolemmal influx in isolated rat ventricular myocytes dose-dependently,which may in part explain its negative inotropic effect." @default.
- W2357954023 created "2016-06-24" @default.
- W2357954023 creator A5002562718 @default.
- W2357954023 date "2007-01-01" @default.
- W2357954023 modified "2023-09-22" @default.
- W2357954023 title "Effects of bupivacaine on intracellular Ca~(2+) in rat ventricular myocytes" @default.
- W2357954023 hasPublicationYear "2007" @default.
- W2357954023 type Work @default.
- W2357954023 sameAs 2357954023 @default.
- W2357954023 citedByCount "0" @default.
- W2357954023 crossrefType "journal-article" @default.
- W2357954023 hasAuthorship W2357954023A5002562718 @default.
- W2357954023 hasConcept C12554922 @default.
- W2357954023 hasConcept C126322002 @default.
- W2357954023 hasConcept C134018914 @default.
- W2357954023 hasConcept C155710745 @default.
- W2357954023 hasConcept C185592680 @default.
- W2357954023 hasConcept C207200792 @default.
- W2357954023 hasConcept C2778233292 @default.
- W2357954023 hasConcept C2781328992 @default.
- W2357954023 hasConcept C29730261 @default.
- W2357954023 hasConcept C55493867 @default.
- W2357954023 hasConcept C71924100 @default.
- W2357954023 hasConcept C79879829 @default.
- W2357954023 hasConcept C86803240 @default.
- W2357954023 hasConcept C98274493 @default.
- W2357954023 hasConceptScore W2357954023C12554922 @default.
- W2357954023 hasConceptScore W2357954023C126322002 @default.
- W2357954023 hasConceptScore W2357954023C134018914 @default.
- W2357954023 hasConceptScore W2357954023C155710745 @default.
- W2357954023 hasConceptScore W2357954023C185592680 @default.
- W2357954023 hasConceptScore W2357954023C207200792 @default.
- W2357954023 hasConceptScore W2357954023C2778233292 @default.
- W2357954023 hasConceptScore W2357954023C2781328992 @default.
- W2357954023 hasConceptScore W2357954023C29730261 @default.
- W2357954023 hasConceptScore W2357954023C55493867 @default.
- W2357954023 hasConceptScore W2357954023C71924100 @default.
- W2357954023 hasConceptScore W2357954023C79879829 @default.
- W2357954023 hasConceptScore W2357954023C86803240 @default.
- W2357954023 hasConceptScore W2357954023C98274493 @default.
- W2357954023 hasLocation W23579540231 @default.
- W2357954023 hasOpenAccess W2357954023 @default.
- W2357954023 hasPrimaryLocation W23579540231 @default.
- W2357954023 hasRelatedWork W1969573866 @default.
- W2357954023 hasRelatedWork W1975463093 @default.
- W2357954023 hasRelatedWork W2008254532 @default.
- W2357954023 hasRelatedWork W2043993270 @default.
- W2357954023 hasRelatedWork W2048127661 @default.
- W2357954023 hasRelatedWork W2068474466 @default.
- W2357954023 hasRelatedWork W2068882685 @default.
- W2357954023 hasRelatedWork W2073891552 @default.
- W2357954023 hasRelatedWork W2076899584 @default.
- W2357954023 hasRelatedWork W2077073771 @default.
- W2357954023 hasRelatedWork W2105999298 @default.
- W2357954023 hasRelatedWork W2288372591 @default.
- W2357954023 hasRelatedWork W2409829880 @default.
- W2357954023 hasRelatedWork W2444692313 @default.
- W2357954023 hasRelatedWork W2895631526 @default.
- W2357954023 hasRelatedWork W2911724981 @default.
- W2357954023 hasRelatedWork W3029005808 @default.
- W2357954023 hasRelatedWork W3031014717 @default.
- W2357954023 hasRelatedWork W3141766377 @default.
- W2357954023 hasRelatedWork W3029812666 @default.
- W2357954023 isParatext "false" @default.
- W2357954023 isRetracted "false" @default.
- W2357954023 magId "2357954023" @default.
- W2357954023 workType "article" @default.