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- W2357967497 abstract "Objective To investigate the protective effects of isoflavones from Astragalus mem- branaceus on apoptosis induced by angiotensinⅡ(AngⅡ)in human umbilical vein endothelial cells(HUVECs)and its possible mechanisms.Methods Cultured HUVECs were randomly di- vided into four groups:control,AugⅡ(1μtool/L),AugⅡ(1μmol/L)+calycosin(1μg/mL),AugⅡ(1μmol/L)+2′-OH-3′,4′-dimethoxyisoflavanone-3-O-β-D-glucopyranoside(1μg/mL).Mor- phology of apoptosis cells was observed by fluorescence microcopy with Hoechst 33258/PI double staining and laser scanning confocal microscope(LSCM).The expression of apoptosis related gene Fas was detected by FCM.Results Compared with the control,treatment with 1μmol/L of angiotensinⅡinduced HUVECs apoptosis,the apoptosis ratio increased gradually(P＜0.001), and Fas expression was upregulated(P＜0.001).LSCM couid distinguish apoptosis cells from normal cells.The injury effects of angiotensinⅡwere inhibited by the treatment of isoflavones from Astragalus membranaceus(P＜0.001).When compared two kinds of isoflavones,no sig- nificant difference was found(P=0.195,P=1,000).Conclusion Isoflavones from Astragalus membranaceus has protective effects on HUVECs by inhibition of angiotensinⅡinduced apop- tosis,suggesting that they may play an important role in prevention and treatment of vascular diseases." @default.
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- W2357967497 date "2007-01-01" @default.
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- W2357967497 title "Protective effects of isoflavones from A stragalus membranaceus on apoptosis of vascular endothelial cells" @default.
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