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- W2357975161 abstract "Objective: To investigate the therapeutic effects and possible immunological mechanism of intravenous injection of Astragalus(黄芪注射液) in neonates with hypoxic ischemic encephalopathy(HIE).Methods: Forty neonates with HIE were divided with the odd or even number of the order for hospitalization into two groups: routine(n=20) and Astragalus treatment groups(n=20).The recovery time of various features of HIE,the time of hospitalization,and the rate of occurrence of organ dysfunctions and complication were compared between the two groups.The interleukin-6(IL-6) and tumor necrosis factor-α(TNF-α) in the plasma and in the supernatant of cultured peripheral blood mononuclearcytes(PBMC) were measured before and after the treatment. Meanwhile,the direct effects of Astragalus injection in vitro on IL-6 and TNF-α production of PBMC were also detected.Results: Compared with the routine treatment group,the recovery time of the abnormal primitive reflexes,muscular tone,disturbance of consciousness and seizures and the time for hospitalization were significantly shortened in intravenous Astragalus treatment group(all P0.05).The incidences of cardiac and renal damages,hyperbilirubinemia and nosocomial infections were markedly decreased(all P0.05).The levels(median) of IL-6 and TNF-α both in the plasma and in the supernatant of PBMC after Astragalus treatment were markedly lower than those before the Astragalus treatment (all P0.01).There were no significant differences in routine group before and after the treatment.The levels of IL-6 and TNF-α production were obviously inhibited with the exposure to Astragalus in vitro in the cultured PBMC of HIE patients(both P0.05).Conclusion: Astragalus might relieve the cerebral damages,multiple organ dysfunctions and shorten the course of HIE by the inhibition of PBMC to produce IL-6 and TNF-α which are injurious cellular factors." @default.
- W2357975161 created "2016-06-24" @default.
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- W2357975161 date "2008-01-01" @default.
- W2357975161 modified "2023-09-22" @default.
- W2357975161 title "A study on clinical effects and immunological mechanism of intravenous Astragalus injection(黄芪注射液) therapy in neonates with hypoxic ischemic encephalopathy" @default.
- W2357975161 hasPublicationYear "2008" @default.
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