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- W2357982014 abstract "Objective To investigate the clinical significance of serum glucose-6-phosphate(GPI) and anti-cyclic citrullinated peptide(CCP) antibody in rheumatoid arthritis(RA).Methods Sera from 41 patients with active RA and 30 healthy controls were analyzed.Levels of GPI and anti-CCP antibody were measured by enzyme linked immunosorbent assay(ELISA) in prior treatment and after 12 and 24 weeks of therapy.Analyze the correlations between levels of GPI and anti-CCP antibody and clinical variables.Results The diagnosis using the level of serum GPI and anti-CCP antibody exhibited the greatest diagnostic sensitivity for RA;they achieved 87.8% and 90.2%,respectively and have no statistical significance.The level of serum GPI and anti-CCP antibody in patients with RA of prior treatment were(3.33 ± 1.88) μg/ml and(84.10 ± 36.26) U/ml.Both of them were significantly higher than those in normal controls(P 0.001).The level of serum GPI showed significantly decrease after 12 and 24 weeks of therapy than prior treatment(P 0.001) in RA patients,but that not in anti-CCP antibody(P 0.05).During prior or post treatment in patients with RA,GPI showed correlations to the RA patient's age,tender joint count,swollen joint count,serum RF titer,ESR,CRP and DAS28 score(P 0.05).Anti-CCP antibodies showed correlations to X-rays of hand joints in patients with RA of prior treatment.Conclusions Both GPI and Anti-CCP antibodies have high RA diagnostic sensitivity.GPI intimately correlated with disease activity of RA and may become a new index to evaluate disease activity.Anti-CCP antibody correlated with X-rays of hand joints in RA patients,but not correlation with disease activity." @default.
- W2357982014 created "2016-06-24" @default.
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- W2357982014 date "2011-01-01" @default.
- W2357982014 modified "2023-09-23" @default.
- W2357982014 title "Significance of diagnoses and treatment that detect glucose-6-phosphate isomerase and anti-cyclic citrullinated peptide antibody in rheumatoid arthritis" @default.
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