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- W2357985697 abstract "Objective To explore the dynamic variation of clotting index in the process of experimental atherosclerosis(AS).Methods Six healthy male New Zealand rabbits were given the high fat diet,and operated in one side of renal artery for stenosis thus leading to high blood pressure.The blood samples were collected from their ear marginal vein to examine prothrombin time(PT),activated partial thromboplastin time(APTT),international normalized ratio(INR) and fibrinogen before the experiment,at the end of 4,8,12,16,20,24 weeks after 24 h fasting.The data were analyzed using repeated measures analysis of variance.Results The levels of PT and INR gradually decreased from the beginning of experiment to the end of 8 weeks,and the levels were significantly lower at each time point than that at the former time point(P0.05),and they became steady from the 12th weekend to 24th weekend.The levels of APTT gradually declined from the beginning of experiment to the end of 12 weeks,and the level was significantly lower at each time point than that at the former time point(P0.05),then it was steady from the 16th weekend to 24th weekend.The level of fibrinogen gradually increased from the beginning of experiment to the end,and the level was higher at each time point than that at the former time point(P0.05).ConclusionIn the process of AS,PT,APTT and INR obviously decrease at the early stage,and then become steady." @default.
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- W2357985697 date "2012-01-01" @default.
- W2357985697 modified "2023-09-27" @default.
- W2357985697 title "Dynamic variation of clotting index in the process of experimental atherosclerosis" @default.
- W2357985697 hasPublicationYear "2012" @default.
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