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- W2357991982 abstract "Objective To find the effect and potential mechanism of ischemic postconditioning relief rCBF and VEGF expression during focal cerebral thrombosis.Methods The thrombotic focal cerebral ischemia was induced by photochemical reaction in tree shrews.The rCBF and VEGF expression in hippocampus CA1 area were detected,by laser-Doppler(LD) fowmeter and immunohistochemistry.Results rCBF reduces along with temporal lasting in cerebral thrombus,especially in 24 h;VEGF expression enhanced after cerebral ischemic,express of VEGF in 12 h is the most intensification(P0.01).Ischemic postconditioning may significant relieve the change of thrombotic focal cerebral ischemia:gradually increase hippocampus rCBF,especially in 72 h(10.42±3.75 PU,P0.05) meanwhile the expression of VEGF was higher than that of ischemic except 8 h(P0.05),mostly in 12 h(P0.01);Electron microscope revealed that mitochondrium stress and endoplasmic reticulum cisterna formation of hippocampus were the most manifest in 24 h,but when we apply postconditioning on it,the phenomenon can be relieived.Conclusion The protection mechanism of ischemic postconditioning may associate with the increase of rCBF in 12 h by intensification the express of VEGF,thus may prolong time window of therapeutic cerebral ischemia." @default.
- W2357991982 created "2016-06-24" @default.
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- W2357991982 date "2008-01-01" @default.
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- W2357991982 title "Ischemic postconditioning increases the change of hippocampus rCBF and VEGF following cerebral Ischemic in tree shrews" @default.
- W2357991982 hasPublicationYear "2008" @default.
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