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- W2357993569 abstract "Background and purpose:TrkB, a neurotrophic tyrosine kinase receptor,serves as a potent and specific suppressor of anoikis of non-malignant epithelial cells, and confers high metastatic capacity to these cells. TrkB over- expression has been found in neuroblastoma and some other high aggressive cancers. This study was to investigate the expression and significance of anoikis-suppressor TrkB in human epithelial ovarian cancer, as well as to evaluate its association with differentiation of ovarian cancer and disease outcome. Methods:The expression of TrkB protein was examined in epithelial ovarian cancer specimens by immunohistochemical staining (ABC method), and confi rmed by RT-PCR at mRNA level. Results:TrkB mRNA was overexpressed in epithelial ovarian cancer specimens, especially in greater omentum metastatic lesions and multicellular spheroids in ascites, andthe ratios of TrkB to β-actin were (31.4±1.4)% and (28.2±0.7)% respectively, compared with corresponding lesions that was (18.1±1.1)% (P0.001). In addition, there was a significant difference of TrkB mRNA between epithelial ovarian cancer specimens and borderline epithelial ovarian tumors, (16.7±3.1)% versus (4.6±0.4)% (P0.001) by RT- PCR. The positive rate of TrkB in patients with epithelial ovarian cancer and borderline epithelial ovarian tumors were 67.12%(49/73) and 14.29%(4/28) respectively,had a signifi cant difference between them (P0.001). Full-length TrkB protein (glycosylated receptor expressed on membrane) was more often overexpressed in multicellular spheroids in ascites(8/8) and high grade carcinomas(34/34) than that in corresponding primary carcinoma(36/73) and low grade carcinomas (3/39,P0.01), but TrkB protein precursor (non-glycosylated receptor expressed in cytoplasm) was overexpressed extensively in epithelial ovarian cancer specimens(49/73) by IHC.The overexpression of TrkB in patients with epithelial ovarian cancer correlated with their bad survival (P0.002). Conclusions:There was a overexpression of TrkB in ovarian epithelial cancer. Full-length TrkB more often was overexpressed in multicellular spheroids in ascites and high grade carcinomas, and TrkB may acts as a anoikis-suppressor in human ovarian epithelial cancer. TrkB maybe a predictor for bad survival of patients with epithelial ovarian cancer." @default.
- W2357993569 created "2016-06-24" @default.
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- W2357993569 date "2008-01-01" @default.
- W2357993569 modified "2023-09-23" @default.
- W2357993569 title "Expression of tyrosine kinase receptor B in human epithelial ovarian cancer and its significance" @default.
- W2357993569 hasPublicationYear "2008" @default.
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