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- W2357996806 abstract "Objective To study the mechanism of apoptosis of astrocytes induced by DXM(Dexamethasone).Methods The brains were obtained from 1-2 days postnatal Wistar rats under sterile condition.Astrocyte suspension was prepared by trypsin digestion for several minutes and the purity of astrocyte was identified using GFAP immunocytochemistry.Pure cultured astrocytes from newborn rat cerebral cortex were incubated with different concentrations of DXM for 24 hours,then the expression of P53 and Bax in astrocytes was measured by immunocytochemical analysis.The results signs by the average optical density.Results The purity of astrocyte was more than 95%,the immunoreactivity for P53 and Bax was markedly increased with the elevation of concentration of DXM.Conclusions These results suggest that the enhanced expression of P53 and Bax may contribute to the apoptosis of astrocytes induced by vast amount of DXM." @default.
- W2357996806 created "2016-06-24" @default.
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- W2357996806 date "2010-01-01" @default.
- W2357996806 modified "2023-09-23" @default.
- W2357996806 title "The effect of DXM on the expression of P53 and Bax in rat astrocytes" @default.
- W2357996806 hasPublicationYear "2010" @default.
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