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- W2358007424 abstract "Objective To observe the effect of Xinfuning Ⅴ on the levels of TXA2 and PGI2 in rat plasma with acute myocardial ischemia.Methods 60 rats were randomly divided into six groups.Rats in control group and model group were intragastrically administered same volume 0.9% sodium chloride injection.Rats in positive group were intragastrically administered isosorbide mononitrate.Rats in different doses Xinfuning Ⅴ groups were intragastrically administered high-,middle-and low-dose Xinfuning Ⅴ,respectively.The course was 14 day in six groups.In 15th days after intragastric administration rats were anesthetized,backlying fixed and recordedⅡ-lead electrocardiogram.Then rat models of acute myocardial ischemia were completed via sublingually intravenous injection of Pit 0.6 U/kg,changes of 2-lead electrocardiogram were recorded.TXA2,PGI2,NO and ET in plasma from carotid after 30min were detected.Results Xinfuning Ⅴin each dose groups can antagonize change of ST segment of electrocardiogram in Pit-induced acute myocardial ischemia.And it can increase the level of NO,decrease the vdume of ET.Xinfuning Ⅴin middle-and high-dose groups can decrease TXA2.Conclusion Xinfuning Ⅴ can against Pit-induced myocardial ischemia.The mechanism may be related to inhibit of TXA2,correct the disbalance of TXA2/PGI2 and adjust NO and ET." @default.
- W2358007424 created "2016-06-24" @default.
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- W2358007424 date "2009-01-01" @default.
- W2358007424 modified "2023-09-23" @default.
- W2358007424 title "Effection of Xinfuning V on the levels of plasma TXA_2 and PGI_2、the volume of NO、ET in rat with acute myocardial ischemia" @default.
- W2358007424 hasPublicationYear "2009" @default.
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