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- W2358020059 abstract "Objective To explore and analyze the correlation between platelet antibody and neonatal thrombocytopenia in pregnant women, and to provide guidance for the clinical prevention of neonatal thrombocytopenia related diseases. Methods Seventy-six pregnant women with thrombocytopenia waiting for delivery at Department of Gynaecology and Obstetrics in our hospital were enrolled as the study group. Seventy-eight pregnant women with normal thrombocyte were selected as the control group. Flow cytometry was adopted to detect and observe the platelet surface antibody, and enzyme-linked immunosorbent assay (ELISA) was used to test and observe the platelet membrane glycoproteins specific autoantibody. The newborns’ platelets were counted. Results Newborns born by the women in the study group had significantly higher incidence of thrombocytopenia (38.16%) than those born by the women in the control group (6.41%), P0.05. The positive detection rate of platelet surface antibody in the study group was 53.95%, significantly higher than the positive detection rate of platelet membrane glycoproteins specific autoantibody (27.63%). The detection sensitivity of platelet surface antibody in the study group was 41.46%, significantly lower than the detection sensitivity of platelet membrane glycoproteins specific autoantibody (95.24%), P0.05. Conclusion Neonatal thrombocytopenia showed a significant correlation with the thrombocytopenia related diseases in pregnant women. Detection of platelet antibody for pregnant women is expected to become the testing index for prevention of neonatal thrombocytopenia." @default.
- W2358020059 created "2016-06-24" @default.
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- W2358020059 date "2013-01-01" @default.
- W2358020059 modified "2023-09-23" @default.
- W2358020059 title "Correlation study of platelet antibody with neonatal thrombocytopenia in pregnant women." @default.
- W2358020059 hasPublicationYear "2013" @default.
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