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- W2358027415 abstract "Objective This paper aimed to explore cytotoxicity and oxidative damage of mesoporous silica SBA-15on human umbilical vein endothelial cells(HUVEC).Methods HUVEC was exposed to the RPMI1640medium containing a final concentration of 0(blank control),25,50,100and 200μg/ml of SBA-15 and cultured for 24h.The survival rate of HUVEC was measured by using Cell Counting Kit-8(CCK-8)method,the apoptosis effect of SBA-15on HUVEC was detected by adopting double staining method with fluorescein isothiocyanate-Annexin V(Annexin V-FITC)and propidium iodide(PI),and the change of ROS level in HUVEC was detected by using dichlorofluorescein diacetate(DCFH-DA)probe method.Results Comparing with the control group(blank group),all the SBA-15solutions had inhibiting effect on the proliferation of HUVEC,and the survival rate of HUVEC droped obviously with the increase of SBA-15concentration(P 0.05).Comparing with the control group,the HUVEC apoptosis rates of the groups contaminated by 50, 100and 200μg/ml SBA-15solutions increased significantly and the cells' ROS level rised with the increase of SBA-15concentration.Conclusions The toxicity effect of SAB-15on endothelial cells can reduce the survival rate of HUVEC;cell apoptosis is one of the indicators by which SBA-15kills HUVEC;oxidative damage may be the important poisoning mechanism of SAB-15to HUVEC." @default.
- W2358027415 created "2016-06-24" @default.
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- W2358027415 date "2014-01-01" @default.
- W2358027415 modified "2023-09-24" @default.
- W2358027415 title "The study on the cytotoxicity andoxidative damage of mesoporous material SBA-15 on HUVEC cells" @default.
- W2358027415 hasPublicationYear "2014" @default.
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