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- W2358032005 abstract "The effect of 5,6-diphenylpy ridazin-3-one derivatives PD032 (2-ethoxycar bonylmethylene-4-cyano-5,6-diphenyl-pyridazin 3-one) on cell traverse of L1210 cell population was studied in this paper. It was shown by flow cytometry that L1210 cell was 45-48% in G1 phase, 46-48% in S phase, 6-8% in G2+M phase. In the cells treated with 2 and 10 μmol/L PD032 for 24 h, there were 2.2% and 3.8% of the cells in G1 phase; 57.9% and 28.8% in S phase; 39.9% and 67.4% in G2+M phase, respectively. The mitotic index (MI) increased from 2 to 7.3% (2μmol/L) and 21% (10μmol/L) after PD032 treatment for 12 h. Augment of the cell vol-umes and multiple nucleus in cells were also observed. The incorporation of [3H]TdR into DNA was slightly inhibited only by 10μmol / L of PD032. The cell traverse reversed in the cells treated with PD032 2μmolk/L (but not PD032 10μmol/L) was observed after incubation of the treated cells in drug free medium for 48 h. These results suggest that DPP derivatives belong to a group of mitotic inhibitors." @default.
- W2358032005 created "2016-06-24" @default.
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- W2358032005 date "1991-01-01" @default.
- W2358032005 modified "2023-09-23" @default.
- W2358032005 title "Effect of 2-ethoxycarbonylmethylene-4-cyano-5, 6-diphenyl pyridazin-3-one on cell cycle of L1210 cells" @default.
- W2358032005 hasPublicationYear "1991" @default.
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