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- W2358043130 abstract "Objective To observe the efficacy of Shengui Yizhi Prescription in the treatment of behavioral disturbance among rats with Alzheimer's disease(AD)and to investigate its action mechanism.Methods Forty Sprague-Dawley rats were randomly and equally divided into blank group,model group,and low-,and high-dose Shengui Yizhi Prescription groups.Beta-amyloid(1-42)was injected into the bilateral hippocampus of rats to induce an AD model.The learning and memory ability was evaluated by Morris water maze(MWM)test.The expression of vascular endothelial growth factor(VEGF),p38mitogen-activated protein kinase(p38 MAPK),and phosphorylated p38 MAPK(p-p38 MAPK)was measured by Western blotting.Results At the end of 4-week treatment,Shengui Yizhi Prescription reduced escape latency(P0.05)and significantly increased the number of platform crossings(P0.05)in a dose-dependent manner,as shown by the MWM test;in addition,it increased the expression of VEGF in the hippocampus and significantly reduced the expression of p-p38 MAPK in the hippocampus in a dose-dependent manner.Conclusion Shengui Yizhi Prescription can reduce behavioral disturbance in AD rats,possibly by increasing VEGF expression and reducing p-p38MAPK in the hippocampus." @default.
- W2358043130 created "2016-06-24" @default.
- W2358043130 creator A5000519074 @default.
- W2358043130 date "2014-01-01" @default.
- W2358043130 modified "2023-09-26" @default.
- W2358043130 title "Effects of Shengui Yizhi Prescription on Expression of Vascular Endothelial Growth Factor and Phosphorylated p38 Mitogen-Activated Protein Kinase in Hippocampus of Rats with Alzheimer's Disease" @default.
- W2358043130 hasPublicationYear "2014" @default.
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