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- W2358045408 abstract "Objective:To develop a liquid chromatography-tandem mass spectrometry method for simultaneous determi- nation of six major cytochrome P450 probe drugs,caffeine(CYP1A2),tolbutamide(CYP2C),omeprazole(CYP2C), dextromethorphan(CYP2D22),ehlorzoxazone(CYP2E1)and midazolam(CYP3A11)in mouse blood.Method:All probe drugs were administered simultaneously and blood samples were handled by precipitation of protein.Following centrif- ugation,the supernatant was analyzed by LC-MS/MS.Dexamethasone was used as a positive control to validate the model. Results:Linear detection responses were obtained for caffeine,tolbutamide and chlorzoxazone concentrations ranging from 20-4 000 ng/ml,for midazolam,omeprazole and dextromethorphan concentrations ranging from 1-200 ng/ml.The intra- and inter-day precision was less than 15%,and recovery was above 90%.Dexamethasone was proved to be an inducer ac- cording to the model.Conclusion:The method was formally validated and showed good performance in terms of linearity, sensitivity,precision and accuracy,and thus can be applied to cytochrome P450 phenotyping studies by an in vivo cocktail in mice." @default.
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- W2358045408 date "2008-01-01" @default.
- W2358045408 modified "2023-09-25" @default.
- W2358045408 title "Phenotyping of six main CYP450 probe drugs in mice by an in vivo cocktail and liquid chromatography-tandem mass spectrometry" @default.
- W2358045408 hasPublicationYear "2008" @default.
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