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- W2358045672 abstract "Objective:To elucidate the characterization of antigen-specific memory T cells from PPD~+ individuals after stimulation with BCG in vitro.Methods:PBMCs were isolated from PPD~ -/+ normal human peripheral blood and stimulated with BCG. The level of IFN-γ in the culture supernatants was assayed by ELISA and the frequency of IFN-γ-producinging cells was detected by ELISPOT. The subsets and frequency of cytokine-producing cells were determined at a single cell level by flow cytometry.Results:After stimulation with BCG, PBMCs from PPD~+ but not PPD~- individuals produced significantly high levels of IFN-γ in culture supernatants detected by ELISA(P0.05), similar results were confirmed with the ELISPOT detection. Flow cytometric analysis indicated that BCG could induce IFN-γ and IL-2 production predominantly by CD4~+T cells but not by CD8~+T cells. Further analysis suggested that 85%~95% CD4~+IFN-γ~+ cells were memory cells in which more than 60% of cells were effector memory(CCR7~+)T cells and the rest of them were central memory T cells(CCR7~-). In addition, 80%~95% of the cells were CD62L~-.Conclusion:BCG could induce the generation of antigen-specific effector/memory CD4~+T cells and maintained in vivo." @default.
- W2358045672 created "2016-06-24" @default.
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- W2358045672 date "2006-01-01" @default.
- W2358045672 modified "2023-09-25" @default.
- W2358045672 title "Characterization of memory T cells following stimulation with BCG" @default.
- W2358045672 hasPublicationYear "2006" @default.
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