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- W2358049198 abstract "Objective To study the effects of pravastatin on BP, lipids, cerebral damage and the endothelial function and morphology in SHRsp. Methods Thirty four SHRsp were randomized into the treatment group and the control group. 20 mg/kg/d pravastatin was given in treatment group and distilled water in the control group for 14 weeks. Serum TC, TG, LDL|c and HDL|c levels and blood pressure were determined. The histological changes in brain and kidney was examined. Immunohistochemical method and RT PCR were performed to explore pravastain's effects on the expression of eNOS in the endothelial cells in carotid artery and aorta. The serums were also measured to estimate the level of NO at the end of the study. Results After 14 weeks, pravastatin had no effect on BP. Serum TC and LDL|c of the treatment group were 34.6% and 43.9% lower than those of the control group(TC:93.1±4.9 md/dl vs 60 8±2.2 mg/dl, P 0 05; LDL|c: 45.7±2.1 mg/dl vs 25 7±1 6 mg/dl, P 0 05). Encephaledema and small artery damages such as elastic lamina injury were manifested in the control group. On the contrary, no obvious pathologic changes in the treatment group was found. Immunochemistry and RT PCR demonstrated the up regulation of eNOS expression in endothelial cells in the treatment group. Serum in the treatment group is significantly higher than that in the control group (34.7±2.5 μmol/L vs 24 4±2 4 μmol/L, P 0 05). Conclusion Pravastatin effectively prevent the cerebral damage of SHRsp. Pravastatin prevention reduce the cholesterol level of SHRsp, improve endothelial function and vascular structure. All of these may contribute to the mechanism of neuroprotective effects by pravastatin." @default.
- W2358049198 created "2016-06-24" @default.
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- W2358049198 date "2002-01-01" @default.
- W2358049198 modified "2023-09-26" @default.
- W2358049198 title "Effect of Pravastatin on Cerebral Damage in SHRsp and its Mechanism" @default.
- W2358049198 hasPublicationYear "2002" @default.
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