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- W2358049304 abstract "OBJECTIVE To investigate the effects of taurine on the expression of proto-oneogene c-fos in the left ventricular hypertrophy in renovascular hypertensive rats. METHODS Two-kidney 1-clip (2K1C) rats were used to reestablish the model of renovascular hypertension. The myocardial collagen concentration (MCC) was measured by biochemical method. The myocardial local aldosterone(Ald) and Ang Ⅱ concentration (MDC, MAC) were measured by radioimmunoassay. The expression of c-fos protein was measured by immanohistochemical method. The expression of proto-oncogene c-fos mRNA was analyzed by means of in situ hybridization. RESULTS Compared with sham operated rats, the systolic blood pressure(SBP), left ventricular weight index (LVWI), MCC, MAC and MDC were significantly increased in 2K1C rats (P0.01). MCC was positively correlated with MAC and MDC, respectively(r=0.8323, 0.9019, P0.01). The expressions of oncogene c-fos mRNA and protein were also obviously higher than that in sham group(P0.01). Taurine(50 mg·kg~(-1)·d~(-1), ig×8 weeks) had an obvious suppressive effect on SBP, LVWI, MCC, MAC, MDC and the expression of proto-oncogene c-fos mRNA and protein(P0.01 for all these indices). CONCLUSION By suppressing myocardial local RAAS and proto-oncogen c-fos expression, taurine can produce good preventive effect on left ventricle hypertrophy caused by renal hypertension." @default.
- W2358049304 created "2016-06-24" @default.
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- W2358049304 date "2005-01-01" @default.
- W2358049304 modified "2023-09-22" @default.
- W2358049304 title "Effects of taurine on expression of proto-oncogene c-fos in left ventricular hypertrophy in renovascular hypertensive rats" @default.
- W2358049304 hasPublicationYear "2005" @default.
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