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- W2358056954 abstract "Objective To observe the effect of atorvastatin on the expression of AB and COX-2 in the brain tissue of rats with vascular dementia.Methods 60 healthy male SD rats were randomly divided into sham-operation group,model group, atorvastatin group(low-dose group and high-dose group).Rat vascular dementia model was prepared by permanent bilateral common carotid arteries occlusion.After 8 weeks,all rats were tested with Morris water maze,and then immunohistochemistry was used to test the expression of AB and COX-2 in the brain.Results Compared with sham-operation group,rats in model group had significantly longer escape latency in orientation navigation experiment(P 0.05),and had obviously decreased the times of crossing the platform in spatial probe test(P 0.05).The expression of AB and COX-2 were up-regulated(P0.05);compared with model group,rats in atorvastatin group had significantly shortened escape latency in orientation navigation experiment(P 0.05 ),and had obviously increased the times of crossing the platform in spatial probe test(P 0.05).The expression of Aβand COX-2 were down-regulated(P0.05);the results of Morris maze test and the expression of AB and COX-2 between the low- dose group and the high-dose group were significantly different(P0.05).Conclusion Atorvastatin may improve the cogni- tion state of rats with vascular dementia by inhibiting the expression of Aβand COX-2 in the brain." @default.
- W2358056954 created "2016-06-24" @default.
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- W2358056954 date "2012-01-01" @default.
- W2358056954 modified "2023-09-22" @default.
- W2358056954 title "Effect of Atorvastatin on the Expression of AB And COX-2 in the Brain Tissue of Rats With Vascular Dementia" @default.
- W2358056954 hasPublicationYear "2012" @default.
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