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- W2358071483 abstract "Objective To investigate the effect of octylphenol and genistein on 7, 12-dimethylbenz[a] anthracene (DMBA)-induced mammary cancer in prepubertal rats. Methods Female SD rats was randomly divided into control group, model group, genistein (GEN) group, octylphenol (OP) group, GEN+OP group. The rats in GEN group, OP group, GEN+OP group were subcutaneously injected with GEN and/or OP from d1 to d7 (the day when the injection began was named as d1, others likewise). DMBA was given to rats except control rats by intragastric administration on d22 and d29. Rats were killed to observe the incidence of breast carcinoma and the changes of histologic pathology on d210, ultrastructure, serum estradiol and progesterone. Results There was no breast tumor in rats of control group. In model group, the incidence of breast carcinoma was 14/21, tumor size and weight were (13.81±2.34) cm~3 and (13.54±2.02) g respectively. In OP group, the incidence of breast carcinoma was 20/21(P0.05). In the groups of GEN and GEN+OP, the incidence of breast tumor were 7/21 (P0.05) and 12/21 respectively, tumor size (3.8±2.3) cm~3 and (4.4±3.7) cm~3 respectively, tumor weight (4.3±3.4) g and (5.3±4.2) g respectively. Histological and ultrastructural analysis showed that cell differentiation were lower in OP group. The cell differentiation were higher and the proliferation of glandular and atypical hyperplasia were more obvious in groups of GEN and GEN+OP. Conclusion Octylphenol maybe accelerate DMBA-induced mammary tumors and genistein can inhibit DMBA-induced breast tumors. The DMBA-induced mammary tumors can be inhibited when rats were treated with genistein and octylphenol." @default.
- W2358071483 created "2016-06-24" @default.
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- W2358071483 date "2005-01-01" @default.
- W2358071483 modified "2023-09-26" @default.
- W2358071483 title "Effect of octylphenol and genistein on 7, 12-dimethylbenz[a] anthracene-induced mammary cancer in rats" @default.
- W2358071483 hasPublicationYear "2005" @default.
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