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- W2358076768 abstract "Objective To explore the association between SNPs in CDH23、PMCA2 and noise-induced hearing loss.Methods SNPs were detected using standard procedures of PCR-RFLP and ASA to identify allele gene.Results According to the result of audiometry,the noise exposed workers were divided into two groups:the NIHL group(n=94)and the normal group(n=100).After adjusting age,sex,and cumulative noise exposure level(CNE)with multiple logistic regression analysis,it was found that the risk of CC genotype in CDH23-rs3802711 was significantly increased than that of TT genotype,the OR value was 0.18(95% confidence interval 0.06～0.49);the risk of GG genotype in CDH23-Exon 7 was significantly increased than that of AA genotype,the OR value was 15.87(95% confidence interval 3.91～64.45);while the risk of AG genotype in PMCA2-rs2289274 was significantly increased than that of the GG genotype,the OR value was 13.60(95% confidence interval 6.09～30.61).Conclusion The results suggested that SNP of rs3802711 and Exon 7 in CDH23,rs2289274 in PMCA2 may be associated with the susceptibility to NIHL." @default.
- W2358076768 created "2016-06-24" @default.
- W2358076768 creator A5045575618 @default.
- W2358076768 date "2012-01-01" @default.
- W2358076768 modified "2023-09-26" @default.
- W2358076768 title "Single nucleotide polymerase in cadherin23,plasma membrance Ca~(2+)-ATPase isoform 2 gene in workers exposed to industrial noise" @default.
- W2358076768 hasPublicationYear "2012" @default.
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