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- W2358090487 abstract "Objective To investigate the damage of cartilage induced by low-dose T-2 toxin,to explore the maximum tolerable daily intake of T-2 toxin in cereals,and to lay a theory foundation for setting up the threshold of T-2 toxin in cereals in the future.Methods A short-term and a subchronic test on rats were respectively carried out to study the toxicity of low-dose T-2 toxin by observing the histopathological changes of transparent cartilage.Results In T-2 toxin groups,the chondrocyte clusters in the growth plate of tibia were disarranged,and the chondrocytes distorted and the amount markedly increased.Due to the crowded chondrocytes,a big cartilage block from growth plate embedded into epiphyseal cartilage end.In high dose group of subchronic test,extension necrosis was seen between proliferating layer and transitional layer.On ultrastructure,chondrocytes were pyknostic,cellular organelles were.vaeuolarly degenerated and decreased in number.Conclusions Osteochondropathia in rat articular growth plate cartilage could be induced by low-dose T-2 toxin in a time-and concentration-dependent manner." @default.
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- W2358090487 date "2007-01-01" @default.
- W2358090487 modified "2023-09-26" @default.
- W2358090487 title "Investigation on histopathology and ultrastructure damages of rat articular growth plate cartilage damage induced by low-dose T-2 toxin" @default.
- W2358090487 hasPublicationYear "2007" @default.
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