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- W2358093079 abstract "Objective To study the relationship between a 160 C/A single nucleotide polymorphism (SNP) of E cadherin (CDH1) gene promoter and relapse of transitional cell carcinoma of the bladder (TCCB).Methods Patients' genotypes for the C/A SNP were determined by analyzing blood DNA of TCCB patients using polymerase chain reaction restriction fragment length polymorphism (PCR RFLP).Recurrence of TCCB was determined by follow up of cystoscopy and subsequent pathological diagnosis of biopsies.Results There were statistically significant differences in relapse rate of TCCB among three genotypes at 160 position of CDH1 gene promoter ( P 0.05), especially,the differences in relapse rate between AA genotype and CC genetype was significant ( P 0.05). Patients with AA genotype and AC genotype had a 4.0 fold and a 1.7 fold higher risk of recurrence of TCCB after initial treatment than those with CC genotype (OR= 4.0566, 95 % CI 1.8325 8.9801; OR= 1.7849, 95 % CI 1.1091 2.8725), respectively.For patients with relapse of TCCB,there was no statistical difference among three genotypes in low differentiation of TCCB ( P 0.05). Conclusion The SNP at 160 position of CDH1 gene promoter may play an important role in relapse of TCCB.It could serve as a prognostic marker for TCCB." @default.
- W2358093079 created "2016-06-24" @default.
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- W2358093079 date "2005-01-01" @default.
- W2358093079 modified "2023-09-25" @default.
- W2358093079 title "Relationship between C/A SNP of the E-cadherin gene promoter and high risk of recurrence of transitional cell carcinoma of the bladder" @default.
- W2358093079 hasPublicationYear "2005" @default.
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