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- W2358103653 abstract "Aim To study the single nucleotide poly-morphism ( SNPs ) of AMP-activated protein kinase ( AMPK) α2 subunit gene PRKAA2 ( rs2051040 and rs17848595) and its relationship with metformin response. Methods A total of 32 patients with type 2 diabetes( T2DM) were enrolled. All patients were required to take metformin for 1 week. The serum levels of FPG,TG,TC,LDL-C,HDL-C were assayed before and after therapy. The gene polymorphism of PRKAA2 was analyzed by PCR-DGGE,the effects of metformin were compared between patients with different phenotypes. Results FPG,TG,TC,LDL-C were significantly improved after therapy in wild genotype carriers( P 0. 05) . The biochemical indexs were not significantly different in mutant genotype carriers after therapy with metformin( P 0. 05) . Conclusion The results of this study suggest that PRKAA2 polymorphism may be associated with metformin treatment effects in T2DM patients." @default.
- W2358103653 created "2016-06-24" @default.
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- W2358103653 date "2010-01-01" @default.
- W2358103653 modified "2023-09-24" @default.
- W2358103653 title "Study on correlation of genetic polymorphism of PRKAA2 with metformin response" @default.
- W2358103653 hasPublicationYear "2010" @default.
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