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• W2358116180 abstract "Objective To investigate the correlations of the levels of sex hormones [follicle stimulating hormone (FSH),luteinizing hormone (LH) and prolactin (PRL)] and lipid profile,malondialdehyde (MDA),superoxide dismutase (SOD) and T lymphocyte subpopulations. Methods Through epidemiological investigations in our country,the levels of sex hormones were measured by radio-immunological methods;lipid profile and apolipoprotein by automatic biochemistry analyses;T cell subsets by flow cytometry;and the MDA was evaluated by the thiobarbituric acid (TBA) test and SOD by the nitrite method modified by Oyanagui,respectively using spectrophotometry. Results In the study women,the concentrations of serum FSH,LH increased significantly after menopause;PRL increased after menopause;compared with the control group in the study population,17β-estradiol (E_2) and progesterone (P) in postmenopausal group reduced obviously,17β-E_2/P reduced significantly after menopause. Testosterone (T) increased significantly after menopause,but not did free testosterone (FT). 17β-E_2,P and the ratio of 17β-E_2/P were negatively correlated with age,respectively by bivariate correlation analysis,and a positive relation between T and age was observed. After the age of 70 years,the level of total cholesterol (TC) increased obviously,so did that of triglyceride (TG) after menopause;high density lipoprotein cholesterol (HDL-C) decreased after menopause,but low density lipoprotein cholesterol (LDL-C) increased after 70,the ratios of HDL-C/TC and HDL-C/LDL-C all reduced after menopause;ApoA-Ⅰ decreased after 70,but ApoB increased significantly after menopause,correspondingly,the ratio of ApoA-Ⅰ/ApoB declined obviously. CD3 + and CD4 + didn't change until 60,but reduced after 60. Compared with that in the control group,CD8 + remained unchanged,CD4 +/CD8 + reduced greatly with aging,and both CD4 + and CD8 + presented a negative correlation with aging. The serum MDA increased notedly after 70,but SOD activity decreased significantly from 60. When the level of 17β-E_2 was graded into four groups according to the quartile (15.66,27.05,57.80 pmol/L),the data showed HDL-C,HDL-C/TC, HDL-C/LDL-C,SOD,CD3 +,CD4 + and CD4 +/CD8 + reduced significantly and the reduction was consistent with the decrease of 17β-E_2,but TG,LDL-C,ApoB behaved adversely. Conclusions The disequilibrium of lipid profile,the correlations of cellular immunological function,lipid peroxides and oxidation system with sex hormones all suggest that the sex hormones play an important role in the process of aging." @default.
• W2358116180 created "2016-06-24" @default.
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• W2358116180 date "2004-01-01" @default.
• W2358116180 modified "2023-09-23" @default.
• W2358116180 title "An investigation about correlations of the levels of sex hormones with lipid profile,malondialdehyde,superoxide dismutase and T lymphocyte subpopulations" @default.
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