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- W2358143414 abstract "Objective To study the influence of antibiotic modeling on intestinal mucosa in mice with dysbacteriotic diarrhea. Methods The mice in normal group were intragastrically administered sterile saline at a dose of 0. 35 m L /( mouse·time),and the mice in the other groups were intragastrically administered antibiotic mixture( cephradine capsules and gentamicin sulfate injection diluted with sterile saline into a concentration of 62. 5m L / L) at a dose of 0. 35 m L /( mouse·time),2 times per day for 5 consecutive days. After the modeling,the jejunum,ileum and colon specimens of mice were collected for measurements of villus height,crypt depth,lymphocyte count and thickness of intestinal mucosa so as to observe the status of intestinal mucosa. Results The crypt depth and thickness of intestinal mucosa of jejunum,ileum and colon of the model mice were not significantly different compared with those in normal group( P 0. 05); the lymphocyte count of the model mice was significantly higher than that in normal group( P 0. 05); the villus height of jejunum of the model mice was significantly lower than that in normal group( P 0. 01). Conclusion The antibiotic modeling of dysbacteriotic diarrhea mice can result in an increased lymphocyte count and decreased villus height in mice." @default.
- W2358143414 created "2016-06-24" @default.
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- W2358143414 date "2015-01-01" @default.
- W2358143414 modified "2023-09-23" @default.
- W2358143414 title "The influence of antibiotic modeling on intestinal mucosa in dysbacteriotic diarrhea mice" @default.
- W2358143414 hasPublicationYear "2015" @default.
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