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- W2358164057 abstract "OBJECTIVE:To establish an HPLC method for the determination of levels of intracellular cholesterol and cholesterol esters in foam cells derived from RAW264.7 murine macrophages so as to obtain a precise measure of foam cells and provide a technical platform for the study of the intracellular cholesterol content change.METHODS:HPLC method was applied to determine the content of cholesterol esters in the foam cells treated with OX-LDL and different concentration of pravastatin.RESULTS:OX-LDL could significantly enhance cellular intake of lipids(P0.01) while pravastatin could lessen the formation of foam cells in a dose-dependent and time-dependent manner(P0.05,P0.01).CONCLUSION:The established HPLC method can be used to determine the levels of intracellular cholesterol and cholesterol esters and detect the formation of cellular foam cells." @default.
- W2358164057 created "2016-06-24" @default.
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- W2358164057 date "2008-01-01" @default.
- W2358164057 modified "2023-09-23" @default.
- W2358164057 title "Content Determination of Cholesterol Esters in Foam Cells Derived from RAW264.7 by HPLC" @default.
- W2358164057 hasPublicationYear "2008" @default.
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