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- W2358172416 abstract "To prepare 10-hydroxycamptothecin-semisolid lipid nanoparticles (HCPT-SSLN) and investigate its stability.HCPT-SSLN was prepared by the method of emulsion evaporation at a high temperature and solidification at a low temperature; The morphology was examined by transmission electron microscope; The particle size and xi potential were determined by laser granularity equipment; The physical stability of both suspl and freeze drying powder of HCPT-SSLN were investigated.The mean particle size of the prepared HCPT-SSLN was 130.5 nm, drug loading was 2.51%, entrapment efficiency was 79.19%, xi potential was -33.1 mV; Placed at room temperature and 4 degrees C for 6 months, the appearance, particle size and entrapment efficiency of HCPT-SSLN were all stable. Moreover, the freeze drying powder was more stable than the suspl.The HCPT-SSLN has high entrapment efficiency and drug loading, uniform particle size, good stability, which initially indicates that HCPT is fit for being incorporated into SSLN." @default.
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- W2358172416 date "2006-01-01" @default.
- W2358172416 modified "2023-09-22" @default.
- W2358172416 title "[Preparation of 10-hydroxycamptothecin semisolid lipid nanoparticles and investigation of its stability]." @default.
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