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- W2358201210 abstract "Objective To study the dosage-time-toxicity relationship of hepatotoxicity induced by single intragastric administration of water extraction from Rhizoma Pinelliae.Methods time-toxicity relationship study:preparing water extraction of 62.5 g·kg-1,ig it of 25 mL·kg-1 to mice once,then get their blood sampling after administration at different times(0,0.5,1,2,4,8,12,24,48,72h).The changes of the activity of ALT,AST and hepar index were detected and the histopathological study was performed;kg-1、70.1 g·kg-1、59.6 g·kg-1、50.7 g·kg-1、43.1 g·kg-1、36.6 g·kg-1,ig them to mice once,while ig distilled water to control group,then do the detecting work 4 hours later as above.Results time-toxicity relationship study indicates that the activity of serum ALT,AST is changing with the time,its toxic peak appears at 4th hour after administration and last for about 48 hours;dosage-toxicity relationship study indicates that the active of serum ALT,AST of high dosage groups were significantly increased than that of normal group.Hepatic tissue pathomorphology examination also shows that hydroncus,fatty degeneration and necrosis in hepatocyte could be induced after administration the high dosage samples,while the low dosage groups have no differences.Conclusion Single intragastric administration of water extraction from Rhizoma Pinelliae with certain dosage may induce acute hepatotoxical injury in mice and show an obvious dosage-time-toxicity relationship." @default.
- W2358201210 created "2016-06-24" @default.
- W2358201210 creator A5059374592 @default.
- W2358201210 date "2011-01-01" @default.
- W2358201210 modified "2023-09-25" @default.
- W2358201210 title "Experimental Study on the Dosage-Time-Toxicity Relationship of Acute Hepatotoxicity Induced by Water Extraction from Rhizoma Pinelliae in Mice" @default.
- W2358201210 hasPublicationYear "2011" @default.
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