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- W2358226437 abstract "Myocardial stunning is the main pathological basis of heart dysfunction after open heart operation, its exact pathogenesis hasn't been clarified until today.In recent years,the molecular and cellular studies have revealed possibly crucial pathogenesis of myocardial stunning that delayed recovery of myocardial glucose oxidation causes intracellular H + accumulation which augments H + Na + exchange thus leading to [Na +] i overload.[Na +] i overload increases Na + Ca 2+ exchange resulting in transient [Ca 2+ ] i overload,which may activate Ca 2+ dependent protease causing partial selective troponin I degradation of myofibris after myocardial ischemia and reperfusion.These progresses provide new theoretic and experimental evidence for further elucidating the pathogenesis of myocardial stunning." @default.
- W2358226437 created "2016-06-24" @default.
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- W2358226437 date "2000-01-01" @default.
- W2358226437 modified "2023-09-25" @default.
- W2358226437 title "Advances in Research of Molecular and Cellular Mechanisms of Myocardial Stunning" @default.
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