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- W2358278617 abstract "Objective To assess vascular endothelium independent dilation function(EID) in the same external iliac artery in hypercholesterolemic(HC) and atherosclerotic rabbits in vivo and in vitro.Methods Thirty six male white big ear rabbits were randomly divided into three groups.Rabbits were fed with normal rabbit chow(group Ⅰ),1% chelesterol diet 2 weeks(group Ⅱ) and 1% cholesterol diet 8 weeks(group Ⅲ).EID to nitroglycerin was examined with high resolution ultrasound and EID to sodium nitroprusside was measured with isolated vascular ring.Results EID was impaired more obviously in group Ⅲ than in group Ⅰ and group Ⅱ in vivo and in vitro.Good correlation existed between the impaired tents of EID measured in vivo and in vitro (r= 0.86 ,P 0.001 ).Endothelium dependent dilation(EDD) impairment occured earlier than EID impairment measured with ultrasound method in vivo.Conclusions Vascular EID dysfunction measured in vivo and in vitro occurred in atherosclerotic rabbits.Noninvasive ultrasound method become a useful surrogate in reflecting nitroglycerin mediated EID in arteries (including coronary artery)." @default.
- W2358278617 created "2016-06-24" @default.
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- W2358278617 date "2000-01-01" @default.
- W2358278617 modified "2023-09-25" @default.
- W2358278617 title "Investigation of vascular endothelium independent dilation function in the external iliac artery of hypercholesterolemic rabbits in vivo and in vitro" @default.
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