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- W2358288047 abstract "Objective To evaluate the expression of dentritic cell(DC)in small airways of COPD model rats,to observe the effects of inhaled budesonide and ipratropium bromide on the COPD model. Methods The rat COPD model (model group)was established by intratracheal instillation of lipopolysaccharide(LPS)twice and exposure to cigarate smoke. Drug inhalation group rats received inhalation of Pulmicort and Atrovently since the second week. The pathologic characteristics of bronchial walls were determinded. At the same time the numbers and the distribution of DCs in each group were investigated by immunohistochemistry. Results COPD model rats showed typical pathological and pathophysiological features. There is a significant increase in DC number in lungs of COPD model group rats compared with the control group rats(P0.01). DC number in budesonide-treatment group also increases,but less than that in model group (P0.01). There are no difference between the ipratropium bromide treatment group with the model group(P0.05). Conclusions There is significant increase in DC number in lungs of COPD model group than control group. Giving budesonide-treatment will reduce this change." @default.
- W2358288047 created "2016-06-24" @default.
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- W2358288047 date "2009-01-01" @default.
- W2358288047 modified "2023-09-23" @default.
- W2358288047 title "Expression of dentritic cells in pulmonary tract of COPD model and effects of intervention" @default.
- W2358288047 hasPublicationYear "2009" @default.
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