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- W2358300443 abstract "OBJECTIVE To investigate the practicability of atenolol gel as a nasal dilivery system by the study of its pharmacokinetics in rabbits.METHODS Twelve rabbits were divided into two groups randomly.The fate of atenolol in the plasma of rabbits was followed after nasal and oral administration of 25 mg of atenolol. Atenolol in plasma was determined by RP-HPLC.The concentration-time data was fitted using 3P97 pharmacokinetic program and the phrmacokinetic parameters were compared by t-test. RESULTS The absorption rate of the nasal gel was faster than that of the oral tablets. The relative bioavailability of atenolol nasal gel was 109.71% .CONCLUSION The atenolol nasal gel had better bioavailability than oral tablets with small difference between individuals." @default.
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- W2358300443 date "2004-01-01" @default.
- W2358300443 modified "2023-10-13" @default.
- W2358300443 title "Pharmacokinetics of atenolol gel for nasal administration in rabbits" @default.
- W2358300443 hasPublicationYear "2004" @default.
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