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- W2358329586 abstract "Objective To observe the effects of chloroquine on glial fibrillary acidic protein (GFAP), proliferating cell nuclear antigen (PCNA) and Cyclin D1 in hippocampal astrocytes and cerebral cortex of rats with epilepsy induced by pentylenetetrazole (PTZ), and to explore the role of chloroquine in the epileptogenesis and development processes. Methods Forty-eight male adult Sprague-Dawley (SD) rats were randomly divided into control group (n=12), PTZ group (60 mg/kg, n=18) and chloroquine intervening group (11.6 g/L, i.c.v., n=18). Each group was further classified into 1, 2, 4, 8, 12, 24 h subgroups. The behavior and electroencephalogram (EEG) of rats were observed and recorded. The expressions of GFAP and PCNA in hippocampus and cerebral cortex were detected with immunohistochemistry. The contents of Cyclin D1 in hippocampus and cerebral cortex were examined with Western blot. Results The control group showed no seizure activity. Severe seizure activity was observed in PTZ group (Ⅲ~Ⅴ class), slight seizure activity (Ⅰ~Ⅲ class) appeared in chloroquine intervening group (P0.05). EEG recordings showed no epileptic spikes in control group, but there were high amplitudes with higher rates in PTZ group, low-amplitude and slow oscillatious in chloroquine intervening group. The expressions of GFAP and PCNA were stronger in PTZ group than those of control group, especially in hippocampal area (P0.05). No significant differences were observed in GFAP and PCNA expressions between chloroquine intervening group and control group (P0.05). The content of Cyclin D1 in PTZ group was significantly higher in hippocampus and cerebral cortex as compared with control and chloroquine intervening group (P0.05), while no significant difference between the latter two groups (P 0.05). Conclusion Chloroquine, by inhibiting the functions and proliferation of glial cells in hippocampus and cerebral cortex, can alleviate the seizure activity, which suggests that chloroquine may be an ideal anticonvulsant in preventing and treating epilepsy." @default.
- W2358329586 created "2016-06-24" @default.
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- W2358329586 date "2006-01-01" @default.
- W2358329586 modified "2023-09-23" @default.
- W2358329586 title "Effects of chloroquine on GFAP, PCNA and Cyclin D1 expressions in hippocampal astrocytes and cerebral cortex of rats with epilepsy induced by pentylenetetrazole" @default.
- W2358329586 hasPublicationYear "2006" @default.
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