Matches in SemOpenAlex for { <https://semopenalex.org/work/W2358331673> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2358331673 abstract "Objective To investigate the effect of Batroxobin on the focal cerebral ischemia-reperfusion(IR)injury in rats and to discuss its possible mechanisms.Methods 72 healthy male Sprague-Dawley rats wererandomized into three groups: group S(Sham operated group,n=24);group IR(IR group,n=24);group BT(Batroxobin treated group,n=24).The rats subjected to middle cerebral artery occlusion with intralimunal filament occlusion were injected intraperitoneally with Batroxobin before reperfusion.Neuroprotective effect of Batroxobin on IR was evaluated in terms of TTC staining and TUNEL assay at 22 hours.In addition,immunoblotting were used to detect nuclear factor-кB(NF-κB),inhibitory protein-κB(IκB),Bcl-2,and Bax expression.Results Compared with the sham group,the cerebral infarct volume ratio and apoptotic cell death were evident in IR-treated rats at 22 hours.Batroxobin significantly decreased all of above parameters compared with the IR group.At a molecular basis,IR significantly increased NF-κB,Bcl-2,and Bax expression while decreased IκB expression.Batroxobin decreased NF-κB and Bax but increased IκB and Bcl-2 expression.Conclusion These findings suggest that Batroxobin treatment have neuroprotective effect against IR injury in the rat,and that this may be associated with upregulation IκB expression and downregulation NF-κB expression." @default.
- W2358331673 created "2016-06-24" @default.
- W2358331673 creator A5067518732 @default.
- W2358331673 date "2006-01-01" @default.
- W2358331673 modified "2023-09-24" @default.
- W2358331673 title "Effects of Batroxobin on the activation of NF-κB after focal cerebral ischemia-reperfusion injury in the rat" @default.
- W2358331673 hasPublicationYear "2006" @default.
- W2358331673 type Work @default.
- W2358331673 sameAs 2358331673 @default.
- W2358331673 citedByCount "0" @default.
- W2358331673 crossrefType "journal-article" @default.
- W2358331673 hasAuthorship W2358331673A5067518732 @default.
- W2358331673 hasConcept C104317684 @default.
- W2358331673 hasConcept C126322002 @default.
- W2358331673 hasConcept C127561419 @default.
- W2358331673 hasConcept C134018914 @default.
- W2358331673 hasConcept C185592680 @default.
- W2358331673 hasConcept C190283241 @default.
- W2358331673 hasConcept C196795494 @default.
- W2358331673 hasConcept C204232928 @default.
- W2358331673 hasConcept C25498285 @default.
- W2358331673 hasConcept C2776641609 @default.
- W2358331673 hasConcept C2777730290 @default.
- W2358331673 hasConcept C2779036427 @default.
- W2358331673 hasConcept C2780114680 @default.
- W2358331673 hasConcept C541997718 @default.
- W2358331673 hasConcept C55493867 @default.
- W2358331673 hasConcept C71924100 @default.
- W2358331673 hasConcept C98274493 @default.
- W2358331673 hasConceptScore W2358331673C104317684 @default.
- W2358331673 hasConceptScore W2358331673C126322002 @default.
- W2358331673 hasConceptScore W2358331673C127561419 @default.
- W2358331673 hasConceptScore W2358331673C134018914 @default.
- W2358331673 hasConceptScore W2358331673C185592680 @default.
- W2358331673 hasConceptScore W2358331673C190283241 @default.
- W2358331673 hasConceptScore W2358331673C196795494 @default.
- W2358331673 hasConceptScore W2358331673C204232928 @default.
- W2358331673 hasConceptScore W2358331673C25498285 @default.
- W2358331673 hasConceptScore W2358331673C2776641609 @default.
- W2358331673 hasConceptScore W2358331673C2777730290 @default.
- W2358331673 hasConceptScore W2358331673C2779036427 @default.
- W2358331673 hasConceptScore W2358331673C2780114680 @default.
- W2358331673 hasConceptScore W2358331673C541997718 @default.
- W2358331673 hasConceptScore W2358331673C55493867 @default.
- W2358331673 hasConceptScore W2358331673C71924100 @default.
- W2358331673 hasConceptScore W2358331673C98274493 @default.
- W2358331673 hasLocation W23583316731 @default.
- W2358331673 hasOpenAccess W2358331673 @default.
- W2358331673 hasPrimaryLocation W23583316731 @default.
- W2358331673 hasRelatedWork W2370787183 @default.
- W2358331673 hasRelatedWork W2409728628 @default.
- W2358331673 hasRelatedWork W2590804131 @default.
- W2358331673 hasRelatedWork W2750050969 @default.
- W2358331673 hasRelatedWork W2981651218 @default.
- W2358331673 hasRelatedWork W3028855906 @default.
- W2358331673 hasRelatedWork W3028898931 @default.
- W2358331673 hasRelatedWork W3029653415 @default.
- W2358331673 hasRelatedWork W3029782414 @default.
- W2358331673 hasRelatedWork W3029784846 @default.
- W2358331673 hasRelatedWork W3029948411 @default.
- W2358331673 hasRelatedWork W3030600647 @default.
- W2358331673 hasRelatedWork W3031298675 @default.
- W2358331673 hasRelatedWork W3031482976 @default.
- W2358331673 hasRelatedWork W3031560562 @default.
- W2358331673 hasRelatedWork W3031686988 @default.
- W2358331673 hasRelatedWork W3031709110 @default.
- W2358331673 hasRelatedWork W3031939697 @default.
- W2358331673 hasRelatedWork W3031963868 @default.
- W2358331673 hasRelatedWork W3037325456 @default.
- W2358331673 isParatext "false" @default.
- W2358331673 isRetracted "false" @default.
- W2358331673 magId "2358331673" @default.
- W2358331673 workType "article" @default.