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- W2358362495 abstract "Objective: To investigate the effects of alcoholic extract of Semen Cuscutae on the antioxidation and the activities of complexⅠand complexⅣ of the respiratory chain of mitochondria in aging mice.Methods:We divided the 50 Kunming mice into 5 groups at random:the young group,the aging group,and the administration groups of 15days,30 days and 45 days.Aging mouse model were made by injecting D-gal.After that,the administration groups begin to be administered with alcoholic extract of Semen Cuscutae.We observed the activity of Mn-SOD,the activities of complexⅠ and complexⅣ of the hepatic mitochondria respiratory chain and the MDA content was measured.At the same time,we observed the changes of these indexes after administration of 15 days,30 days and 45 days.Result:D-gal induced mouse aging.Compared with the young group,the Mn-SOD activity and the activities of complexⅠand complexⅣ of the respiratory chain were decreased in hepatic mitochondria(P0.05),while the MDA content was increased(P0.05).The alcoholic extract of Semen Cuscutae increased the Mn-SOD activity,and the activities of complexⅠand complexⅣ of the respiratory chain.Conclusion:The alcoholic extract of Semen Cuscutae can enhance the activities of complexⅠand complexⅣ of the respiratory chain by decreasing the content of metabolite of free radicle and increase Mn-SOD activity of hepatic mitochondria.The longer administration,the better effect." @default.
- W2358362495 created "2016-06-24" @default.
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- W2358362495 date "2008-01-01" @default.
- W2358362495 modified "2023-09-27" @default.
- W2358362495 title "Effects of alcoholic extract of Semen Cuscutae on oxidative damage and complex activities of hepatic mitochondria respiratory chain of aging mice" @default.
- W2358362495 hasPublicationYear "2008" @default.
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