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- W2358399772 abstract "To study the protective effects of BAPTA-AM liposome(BA-L) on D-galactosamine and lipopolysaccharide induced acute liver failure in mice,mice were treated with D-GalN and LPS to induce acute liver failure.BA-L of different doses was administered intravenously before D-GalN/LPS injection.The mortality,liver index,percent of water in liver,serum levels of alanine aminotransferase(ALT) and nitric oxide(NO),hepatic tissue glutathione(GSH),glutathione peroxidase(GSH-Px),superoxide dismutase(SOD) and malondialdehyde(MDA) were measured.Hematoxylin and eosin(HE) stain and Terminal deoxynucleotidyl transferase-mediated UDP nick-end labeling(TUNEL) assay was used to evaluate pathologic changes and apoptotic index of hepatic tissue.BA-L could significantly decrease the mortality rate,the liver index,the serum levels of ALT and NO,the hepatic tissue level of MDA,increase the hepatic tissue GSH level,GSH-Px and SOD activity in ALF mice.BA-L alleviated D-GalN/LPS induced severe injury of hepatic tissue,and decreased apoptotic index remarkably.Besides,both of the potency and efficacy of BA-L are far higher than those of diammonium glycyrrhizinate.BA-L exert admirable protection against D-galactosamine and lipopolysaccharide induced acute liver failure in mice." @default.
- W2358399772 created "2016-06-24" @default.
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- W2358399772 date "2013-01-01" @default.
- W2358399772 modified "2023-09-26" @default.
- W2358399772 title "Protection of BAPTA-AM against D-galactosamine and lipopolysaccharide induced acute liver failure in mice" @default.
- W2358399772 hasPublicationYear "2013" @default.
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