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- W2358443344 abstract "Purpose:To investigate the expressions of transforming growth factor β1 (TGFβ1) in benign prostatic hyperplasia (BPH) on the level of mRNA and protein.Method:To detect the expressions of TGFβ1 mRNA of BPH and protein in 22 cases of human BPH 10 cases of normal prostatic (NP) specimens by mRNA in situ hybridization and immunohistochemistry.Results:Obvious expression of TGFβ1 mRNA was found in the epithelial and mysenchymal of BPH and NP,no significant difference was found between BPH and NP (P 0.05);the expression of TGFβ1 mRNA in stromal cells was significantly higher than that in epithelial cells in BPH or NP respectively (P 0.01).Immunoreactivity for TGFβ1 protein was positive in mysenchymal of all prostatic tissue,however weakly positive or negative in epithelium.The level of immunostaining for TGFβ1 in mysenchymal of BPH was significantly higher than that in NP (P 0.01),especially in the proliferative nodes containing mainly of stroma.Conclusion:TGFβ1 might be a causative factor in mysenchymal proliferation of BPH,the starting and promoting factor of BPH regulates the expression of TGFβ1 on the level of posttranscription." @default.
- W2358443344 created "2016-06-24" @default.
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- W2358443344 date "2001-01-01" @default.
- W2358443344 modified "2023-09-25" @default.
- W2358443344 title "Expression of TGF_(β1)in benign prostatic hyperplasia" @default.
- W2358443344 hasPublicationYear "2001" @default.
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