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- W2358443670 abstract "Objective To investigate the quantity and function of circulating dendritic cell (DC) subsets in patients with chronic hepatitis B virus (HBV) infection and to analyze their biological significance. Methods Phenotype molecules of DC1 were determined both in patients with chronic HBV infection and healthy people. We also used PBMCs to investigate PDC function. IFN-α production of HBV-infected patients and normal controls was determined by ELISA method. Results The frequency and cell number of circulating MDC were 0.45%±(0.14%) and (11.3±6.3)×10~6/L separately in healthy people,which decreased in patients with liver cirrhosis (LC) compared with that in normal controls. However, PDC frequency and number were 0.36%±0.15% and (8.9±4.2)×10~6/L,which decreased both in patients with chronic hepatitis B (CHB) and LC. DC1 cultured from CHB patients showed less expression of CD80 and CD86 in comparison with that in normal controls. The ability of PBMCs to secrete IFN-α also significantly decreased in patients. Conclusion The results suggested that patients with chronic HBV infection have a quantitative and qualitative change of DC subsets, which may partly contribute to HBV disease progression in these patients. [" @default.
- W2358443670 created "2016-06-24" @default.
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- W2358443670 date "2004-01-01" @default.
- W2358443670 modified "2023-09-28" @default.
- W2358443670 title "Characterization and biological significance of peripheral dendritic cell subsets in human hepatitis B infection" @default.
- W2358443670 hasPublicationYear "2004" @default.
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