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- W2358450154 abstract "Objective To investigate the mechanism of renal cell carcinoma (RCC) in affecting the immune system of the host. Methods FasL expression and the apoptosis of tumor infiltrating lymphocytes (TIL) were examined by immunohistochemical technique in 44 cases of RCC.FasL function was assessed by coculture assays in vitro using the renal cancer cells 786 0 or GRC 1 and the Fas sensitive Jurkat T cells. Results (1)FasL expression rate in RCC (46.5%) was higher than that in the normal kidney tissues (23.2%, P 0.01). The expression rate of FasL in RCC was significantly increased correlating with RCC stage ( P 0.01). The expression of FasL with Ki67 had a positive correlation ( r= 0.93,P 0.01).(2)The apoptotic rate of TIL in RCC (33.9%) was significantly higher than that of the normal kidney tissues (3.5%, P 0.01).The expression of FasL and the apoptotic rate of TIL in RCC had a positive correlation with each other ( r=0.96,P 0.01).(3)The FasL expression rate of 786 0 (18.6%) was higher than that of GRC 1 (2.3%, P 0.01). FasL expressed by 786 0 cells could induce apoptosis of Jurkat T cells in coculture assays and apoptosis of Jurkat T cells was significantly decreased after blocking the effect of FasL with Fas neutralizing antibody NOK 2,the apoptotic rates being 14.9% and 2.0% respectively ( P 0.01).The apoptotic rate of Jurkat T cells cocultured with GRC 1 was 1.3%,being significantly lower than that of Jurkat T cells cocultured with 786 0 ( P 0.01 ). Conclusions FasL expressed by renal cancer cells could induce T cell apoptosis,playing a cardinal role in affecting the immune system of the host." @default.
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- W2358450154 date "2002-01-01" @default.
- W2358450154 modified "2023-09-26" @default.
- W2358450154 title "Role of FasL in affecting immune system of the host in renal cell carcinoma" @default.
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