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- W2358468665 abstract "Objective To investigate the role of CDKL3 in the development of neuronal spines and further reveal the underlying relationship between CDKL3 inactivation and the non-syndromic mild mental retardation(MR).Methods The distribution and expression of Cdkl3 mRNA in developing nervous system in mouse were investigated by method of RT-Quantitive PCR.The role of CDKL3 in the development of neuronal spines in vivo were studied by the method of RNA interference and immunofluorescence.Results RT-PCR result showed that Cdkl3 mRNA was detectable at the 14th day,and reached its peak at birth.Afterwards,it declined slightly and was maintained at low level from the 14th day after birth to adulthood.CDKL3 depletion inhibited the formation of spines,whereas CDKL3 upregulation had the opposite effects,and the co-expression of CDKL3-Res prevented the shRNA-#2-mediated defects.Conclusions CDKL3 played a critical role in the development of neuronal spines.Furthermore,CDKL3 inactivation maybe contribute to non-syndromic mild MR by affecting spines morphogenesis during crucial stages of their formation." @default.
- W2358468665 created "2016-06-24" @default.
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- W2358468665 date "2011-01-01" @default.
- W2358468665 modified "2023-09-28" @default.
- W2358468665 title "The role of non-syndromic mild mental retardation candidate gene CDKL3 in the development of neuronal dendrites spine" @default.
- W2358468665 hasPublicationYear "2011" @default.
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