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- W2358469660 abstract "Objective: To observe the effect of immune functiom in sepsis mice and to study the mechanism. Methods: The models of sepsis was created with Cecalligation and puncture(CLP) and adult male BALB/c mice were divided randomly into 6 groups, Sham operation group, CLP group, group with positive drug(Methylprednisolone), Tan Re Qing injection large, medium and small doses group. The inflammatory cytokines in the serum were detected by the methods of cytometric bead array. Speci-mens were collected to examine the lymphocyte count in the thymus and spleen and test T and B lymphocyte multiplication function,Results: The levels of TNF-α, IL-6 and IL-10 in the blood were dramatically elevated after CLP. The thymus and spleen of the mice significantly atrophied; both the lymphocyte count and the T and B lymphocyte multiplication function are reduced. After CLP, TRQ and Methylprednisolone had evident effect on inhibiting the increase of inflammatory cytokine, and those drugs remarkably enhanced the indexes thymus and spleen. Both thymus and spleen lymphocyte count also markedly in-creased in the three groups of TRQ medicine and hymus and spleen lymphocyte multiplication function increased. Conclusion: TRQ could effectively inhibit inflammatory reaction of the immune system caused by sepsis and protect l sepsis mice." @default.
- W2358469660 created "2016-06-24" @default.
- W2358469660 creator A5024960243 @default.
- W2358469660 date "2014-01-01" @default.
- W2358469660 modified "2023-09-23" @default.
- W2358469660 title "Study on the Effect of Tan Re Qing Injection on Immune Function in Sepsis Mice" @default.
- W2358469660 hasPublicationYear "2014" @default.
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