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- W2358486513 abstract "Microarrays are at the center of a revolution in biotechnology, allowing researchers to simultaneously monitor the expression of tens of thousands of genes, having been widely used in medical research. The main challenge faced by the researchers is to extract useful information from such gene expression profiles and then implement biological interpreta- tion of such results. At present, all kinds of different research groups based on pre-defined gene set proposed different enrichment analysis methods. In this paper, these methods will be roughly divided into two categories: bottom-up approach and top-down approach. The former approach tested genes individually first then aggregated by biological knowledge. This approach was widely used, and its results were easier to explain than the results of the single gene analysis. The latter approach performed domain aggregation by first combining gene expressions before testing for differentially expressed patterns. This method can not only increase interpretability of analysis output, but also reach dimension reduction purposes." @default.
- W2358486513 created "2016-06-24" @default.
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- W2358486513 date "2008-01-01" @default.
- W2358486513 modified "2023-09-24" @default.
- W2358486513 title "Progress on Enrichment Analysis Approach of Gene Expression Profiles" @default.
- W2358486513 hasPublicationYear "2008" @default.
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