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- W2358492605 abstract "Objective To observe fundus, angiographic and histological changes of rabbit eyes in which human fetal RPE cells were transplanted into subretinal spaces. To determine if intravitreal injection of Cyclosporine (CsA) can prevent the rejection of human fetal RPE xenografts to rabbit retina. Methods RPE patches and concentrated RPE cell suspension from human fetal eyes were transplanted into subretinal spaces of 36 rabbit eyes. In control group, the eyes were removed for histological examination at 7d (8 eyes) and 30d (8 eyes). Some rabbits (4 eyes) were received vehicle injection for comparison. The remaining twenty eyes received weekly intravitreal CsA 1mg (12 eyes) or 0.1mg (8 eyes) injection. The ERG was recorded to check retinal toxicity of CsA and vehicle. Results Both RPE patches and concentrated RPE cell suspension from human fetal eyes can survive in subretinal spaces of rabbit eyes. Transplanted RPE kept good contact with visual cells and phagocytized outer disks. In control group, rejection rate was 0/8 in one week and 7/8 in four weeks. The transplanted area was hyperfluorescent in angiography and also heavily infiltrated by large amounts of histocytes. In CsA treated group, the rejection rate at one month was 0/12 with 1 mg of CsA and 5/8 for 0.1mg injection. The ERG showed a CsA dose and time dependent reduction. Conclusion The survival time of human fetal RPE xenografts is very limited in the subretinal spaces if immunosuppressive agents aren't administered. Intravitreal CsA delays rejection of RPE xenografts in rabbits but causes marked retinal toxicity." @default.
- W2358492605 created "2016-06-24" @default.
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- W2358492605 date "2001-01-01" @default.
- W2358492605 modified "2023-09-26" @default.
- W2358492605 title "Inhibitory effects of Cyclosporine intravitreal injection to retinal pigment epithelium xenografts in sub-retinal spaces" @default.
- W2358492605 hasPublicationYear "2001" @default.
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