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- W2358492754 abstract "In order to direct treatment research on diabetic erectile dysfunction(ED),we studied the pathogenesis of diabetic erectile dysfunction from several factors such as neural factor,vascular factor and ion tunnel. Male Sprague-Dawley rats were injected with 65 mg/kg streptozotocin to induce diabetes mellitus(DM).Eight weeks later,the erection function of the rats were measured by apomorphine injection.The intercavernous pressure(ICP) of the normal and diabetic rats with ED were measured by electrostimulation before being sacrificed.Each peeled penis was divided into several parts.We detected the three subtypes of nitric oxide synthase(NOS) in cavernous tissues of normal and diabetic ED rats,including neural NOS(nNOS),endothelial NOS(eNOS),induced NOS(iNOS),by immunohistochemistry.The level of angiotension II(AngII) was dectected by radioimmunoassay.Then we used Western Blot analysis to detect the distribution of nerve growth factor(NGF),vascular endothelial growth factor(VEGF) and connexin-43 in cavernous tissues.Comparing the result with that of normal rates,we found that the mean of ICP in diabetic ED rats was significantly decreased.The positive staining cells of eNOS and nNOS were significantly decreased while that of iNOS was increased.The protein expression of NGF was up-regulated.The AngII level in cavernous was significantly raised.The protein expression of VEGF and connexin 43 was down-regulated.In conclusion,we found that the pathogenesis of diabetic ED was very complex,involved in nerve,neurotransmitter,blood vessel,endothelial function,metabolism,endocrine and so on.In our basic researches and clinical work,we should use combined therapy according to the multifactorial pathogenesis of diabetic ED,in order to elevate the therapeutic effect." @default.
- W2358492754 created "2016-06-24" @default.
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- W2358492754 date "2006-01-01" @default.
- W2358492754 modified "2023-09-25" @default.
- W2358492754 title "The Study of Multifactorial Pathogenesis of Diabetic Erectile Dysfunction" @default.
- W2358492754 hasPublicationYear "2006" @default.
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