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- W2358505212 abstract "Sclerosing hemangioma (SH) of the lung is an uncommon benign tumor of uncertain histogenesis that is composed of two major cell types: surface and polygonal cells. 6 cases of SH were observed with electron microscope and analyzed in conjunction with its histopathologic and immunohistochemical( CK,EMA,TTF 1, CgA and SyN) observations. SH presented as a predilection for woman (5/6) and showed four distinct patterns (papillary, sclerotic, solid and hemorrhagic) with a variable proportion. Ultrastructural observation showed that the surface cells with variable short microvilli have the greater number of cytoplasmic organelles including abundant rough endoplasmic reticulum and mitochondria. Polygonal cells have lighter cytoplasm with sparse organelles. Variable electron dense bodies of different sizes (range, 0.3～1.2μm) and shapes were present. Obvious secretory granules and osmophilic lamellar bodies were not shown. There were 100% positive for CK, EMA and TTF 1 expression. CgA and SyN were predominantly negative despite a few of scatter positive cells in solid areas of 1 case. It was suggested that SH is an epithelial neoplasm derived from primitive respiratory epithelium. The different expressions of CK and EMA on surface and polygonal cells may present variable differentiation from a progenitor cell. Few of tumor cells may have the differentiation of clara cells." @default.
- W2358505212 created "2016-06-24" @default.
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- W2358505212 date "2001-01-01" @default.
- W2358505212 modified "2023-09-25" @default.
- W2358505212 title "Ultrastructural observation of sclerosing hemangioma of the lung" @default.
- W2358505212 hasPublicationYear "2001" @default.
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