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- W2358505856 abstract "Objective To study the bioavailability of the test mosapride citrate dispersant and evaluate its bioequivalance comparaed to the reference mosapride citrate tablet. Methods A single oral dose of 10mg mosapride citrate from either the test dispersant or its reference tablet was given to 22 healthy male volunteers according to a randomized cross-over design. The mosapride citrate concentration in plasma was determined by HPLC method. The pharmacokinetic and bioavailability of the test dispersant were compared with the reference tablet. Results The main pharmacokinetic parameters as follow: AUC0-t were 117.64 ±36.88, 113.33±41.11 μg·h·L-1, Cmax were 67.27±27.27 and 62.67±25.68 μg·L-1, tmax were 0.50 ± 0.23 and 0.75 ±0.3 1h for test and reference, respectively. The relative bioavailability of the test mosapride citrate dispersant was (107.6 ± 24.7)% of the reference tablet. Conclusion Through the one two-sided test and the analysis of covariance, no significant difference between the pharmacokinetic parameters of the two formulations was found. The two formulations are bioequivalent. However, the tmax of the test mosapride citrate dispersant was shorter than the reference tablet." @default.
- W2358505856 created "2016-06-24" @default.
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- W2358505856 date "2004-01-01" @default.
- W2358505856 modified "2023-09-25" @default.
- W2358505856 title "Relative bioavailabillty of mosapride citrate dispersant in healthy volunteers" @default.
- W2358505856 hasPublicationYear "2004" @default.
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